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Progress update from the hippocampal subfields group.

  • Author(s): Olsen, Rosanna K
  • Carr, Valerie A
  • Daugherty, Ana M
  • La Joie, Renaud
  • Amaral, Robert SC
  • Amunts, Katrin
  • Augustinack, Jean C
  • Bakker, Arnold
  • Bender, Andrew R
  • Berron, David
  • Boccardi, Marina
  • Bocchetta, Martina
  • Burggren, Alison C
  • Chakravarty, M Mallar
  • Chételat, Gaël
  • de Flores, Robin
  • DeKraker, Jordan
  • Ding, Song-Lin
  • Geerlings, Mirjam I
  • Huang, Yushan
  • Insausti, Ricardo
  • Johnson, Elliott G
  • Kanel, Prabesh
  • Kedo, Olga
  • Kennedy, Kristen M
  • Keresztes, Attila
  • Lee, Joshua K
  • Lindenberger, Ulman
  • Mueller, Susanne G
  • Mulligan, Elizabeth M
  • Ofen, Noa
  • Palombo, Daniela J
  • Pasquini, Lorenzo
  • Pluta, John
  • Raz, Naftali
  • Rodrigue, Karen M
  • Schlichting, Margaret L
  • Lee Shing, Yee
  • Stark, Craig EL
  • Steve, Trevor A
  • Suthana, Nanthia A
  • Wang, Lei
  • Werkle-Bergner, Markus
  • Yushkevich, Paul A
  • Yu, Qijing
  • Wisse, Laura EM
  • Hippocampal Subfields Group
  • et al.
Abstract

Introduction:Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods:Our international working group, funded by the EU Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results:This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion:A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

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