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PINK1-Based Screen Shines Light on Autophagy Enhancers for Parkinson’s Disease
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https://doi.org/10.1016/j.chembiol.2017.04.002Abstract
In this issue of Cell Chemical Biology, Zhang et al. (2017) report a zebrafish model of Parkinson's disease (PD), incorporating the PD-protein PINK1 and rotenone, a toxin linked to PD. Using it as a drug-screening platform, they identify trifluoperazine and other piperazine phenothiazines as protective compounds that enhance autophagy independent of PINK1.
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