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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- Mariathasan, Sanjeev;
- Turley, Shannon J;
- Nickles, Dorothee;
- Castiglioni, Alessandra;
- Yuen, Kobe;
- Wang, Yulei;
- Kadel III, Edward E;
- Koeppen, Hartmut;
- Astarita, Jillian L;
- Cubas, Rafael;
- Jhunjhunwala, Suchit;
- Banchereau, Romain;
- Yang, Yagai;
- Guan, Yinghui;
- Chalouni, Cecile;
- Ziai, James;
- Şenbabaoğlu, Yasin;
- Santoro, Stephen;
- Sheinson, Daniel;
- Hung, Jeffrey;
- Giltnane, Jennifer M;
- Pierce, Andrew A;
- Mesh, Kathryn;
- Lianoglou, Steve;
- Riegler, Johannes;
- Carano, Richard AD;
- Eriksson, Pontus;
- Höglund, Mattias;
- Somarriba, Loan;
- Halligan, Daniel L;
- van der Heijden, Michiel S;
- Loriot, Yohann;
- Rosenberg, Jonathan E;
- Fong, Lawrence;
- Mellman, Ira;
- Chen, Daniel S;
- Green, Marjorie;
- Derleth, Christina;
- Fine, Gregg D;
- Hegde, Priti S;
- Bourgon, Richard;
- Powles, Thomas
Published Web Location
https://doi.org/10.1038/nature25501Abstract
In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.
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