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Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells

  • Author(s): Krogan, Nevan
  • Tosti, E
  • Katakowski, JA
  • Schaetzlein, S
  • Kim, HS
  • Ryan, CJ
  • Shales, M
  • Roguev, A
  • Krogan, NJ
  • Palliser, D
  • Keogh, MC
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4189729?pdf=render
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Abstract

© 2014 Tosti et al.; licensee BioMed Central Ltd.Background: The evolutionarily conserved DNA mismatch repair (MMR) system corrects base-substitution and insertion-deletion mutations generated during erroneous replication. The mutation or inactivation of m

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