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Common variants at 19p13 are associated with susceptibility to ovarian cancer
- Bolton, Kelly L;
- Tyrer, Jonathan;
- Song, Honglin;
- Ramus, Susan J;
- Notaridou, Maria;
- Jones, Chris;
- Sher, Tanya;
- Gentry-Maharaj, Aleksandra;
- Wozniak, Eva;
- Tsai, Ya-Yu;
- Weidhaas, Joanne;
- Paik, Daniel;
- Van Den Berg, David J;
- Stram, Daniel O;
- Pearce, Celeste Leigh;
- Wu, Anna H;
- Brewster, Wendy;
- Anton-Culver, Hoda;
- Ziogas, Argyrios;
- Narod, Steven A;
- Levine, Douglas A;
- Kaye, Stanley B;
- Brown, Robert;
- Paul, Jim;
- Flanagan, James;
- Sieh, Weiva;
- McGuire, Valerie;
- Whittemore, Alice S;
- Campbell, Ian;
- Gore, Martin E;
- Lissowska, Jolanta;
- Yang, Hanna P;
- Medrek, Krzysztof;
- Gronwald, Jacek;
- Lubinski, Jan;
- Jakubowska, Anna;
- Le, Nhu D;
- Cook, Linda S;
- Kelemen, Linda E;
- Brooks-Wilson, Angela;
- Massuger, Leon FAG;
- Kiemeney, Lambertus A;
- Aben, Katja KH;
- van Altena, Anne M;
- Houlston, Richard;
- Tomlinson, Ian;
- Palmieri, Rachel T;
- Moorman, Patricia G;
- Schildkraut, Joellen;
- Iversen, Edwin S;
- Phelan, Catherine;
- Vierkant, Robert A;
- Cunningham, Julie M;
- Goode, Ellen L;
- Fridley, Brooke L;
- Kruger-Kjaer, Susan;
- Blaeker, Jan;
- Hogdall, Estrid;
- Hogdall, Claus;
- Gross, Jenny;
- Karlan, Beth Y;
- Ness, Roberta B;
- Edwards, Robert P;
- Odunsi, Kunle;
- Moyisch, Kirsten B;
- Baker, Julie A;
- Modugno, Francesmary;
- Heikkinenen, Tuomas;
- Butzow, Ralf;
- Nevanlinna, Heli;
- Leminen, Arto;
- Bogdanova, Natalia;
- Antonenkova, Natalia;
- Doerk, Thilo;
- Hillemanns, Peter;
- Dürst, Matthias;
- Runnebaum, Ingo;
- Thompson, Pamela J;
- Carney, Michael E;
- Goodman, Marc T;
- Lurie, Galina;
- Wang-Gohrke, Shan;
- Hein, Rebecca;
- Chang-Claude, Jenny;
- Rossing, Mary Anne;
- Cushing-Haugen, Kara L;
- Doherty, Jennifer;
- Chen, Chu;
- Rafnar, Thorunn;
- Besenbacher, Soren;
- Sulem, Patrick;
- Stefansson, Kari;
- Birrer, Michael J;
- Terry, Kathryn L;
- Hernandez, Dena;
- Cramer, Daniel W;
- Vergote, Ignace;
- Amant, Frederic;
- Lambrechts, Diether;
- Despierre, Evelyn;
- Fasching, Peter A;
- Beckmann, Matthias W;
- Thiel, Falk C;
- Ekici, Arif B;
- Chen, Xiaoqing;
- Johnatty, Sharon E;
- Webb, Penelope M;
- Beesley, Jonathan;
- Chanock, Stephen;
- Garcia-Closas, Montserrat;
- Sellers, Tom;
- Easton, Douglas F;
- Berchuck, Andrew;
- Chenevix-Trench, Georgia;
- Pharoah, Paul DP;
- Gayther, Simon A
- et al.
Published Web Location
https://doi.org/10.1038/ng.666Abstract
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10⁻⁴ and P = 6 × 10⁻⁴, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10⁻⁹ and P = 4 × 10⁻¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
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