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Delphi definition of the EADC‐ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance
- Boccardi, Marina;
- Bocchetta, Martina;
- Apostolova, Liana G;
- Barnes, Josephine;
- Bartzokis, George;
- Corbetta, Gabriele;
- DeCarli, Charles;
- deToledo‐Morrell, Leyla;
- Firbank, Michael;
- Ganzola, Rossana;
- Gerritsen, Lotte;
- Henneman, Wouter;
- Killiany, Ronald J;
- Malykhin, Nikolai;
- Pasqualetti, Patrizio;
- Pruessner, Jens C;
- Redolfi, Alberto;
- Robitaille, Nicolas;
- Soininen, Hilkka;
- Tolomeo, Daniele;
- Wang, Lei;
- Watson, Craig;
- Wolf, Henrike;
- Duvernoy, Henri;
- Duchesne, Simon;
- Jack, Clifford R;
- Frisoni, Giovanni B;
- Segmentation, EADC‐ADNI Working Group on the Harmonized Protocol for Manual Hippocampal
Published Web Location
https://doi.org/10.1016/j.jalz.2014.02.009Abstract
Background
This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.Methods
The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.Results
Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.Discussion
Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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