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TGF-β mediated DNA methylation in prostate cancer.

  • Author(s): Lee, Chung
  • Zhang, Qiang
  • Zi, Xaolin
  • Dash, Atreya
  • Soares, Marcelo B
  • Rahmatpanah, Farahnaz
  • Jia, Zhenyu
  • McClelland, Michael
  • Mercola, Dan
  • et al.
Creative Commons Attribution 4.0 International Public License
Abstract

Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.

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