Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
- Author(s): Hersman, S
- Cushman, J
- Lemelson, N
- Wassum, K
- Lotfipour, S
- Fanselow, MS
- et al.
Published Web Locationhttps://doi.org/10.1038/s41598-017-02542-1
© 2017 The Author(s). Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.
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