Skip to main content
eScholarship
Open Access Publications from the University of California

Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations

  • Author(s): Hersman, S
  • Cushman, J
  • Lemelson, N
  • Wassum, K
  • Lotfipour, S
  • Fanselow, MS
  • et al.
Abstract

© 2017 The Author(s). Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View