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Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

  • Author(s): Kim, Youngchang
  • Jedrzejczak, Robert
  • Maltseva, Natalia
  • Endres, Michael
  • Godzik, Adam
  • Michalska, Karolina
  • Joachimiak, Andrzej
  • et al.


Severe Acute Respiratory Syndrome Coronavirus 2 is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report the high-resolution crystal structure of endoribonuclease Nsp15/NendoU from SARS-CoV-2 – a virus causing current world-wide epidemics. We compare this structure with previously reported models of Nsp15 from SARS and MERS coronaviruses.

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