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Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

  • Author(s): Schumacher, Fredrick R;
  • Schmit, Stephanie L;
  • Jiao, Shuo;
  • Edlund, Christopher K;
  • Wang, Hansong;
  • Zhang, Ben;
  • Hsu, Li;
  • Huang, Shu-Chen;
  • Fischer, Christopher P;
  • Harju, John F;
  • Idos, Gregory E;
  • Lejbkowicz, Flavio;
  • Manion, Frank J;
  • McDonnell, Kevin;
  • McNeil, Caroline E;
  • Melas, Marilena;
  • Rennert, Hedy S;
  • Shi, Wei;
  • Thomas, Duncan C;
  • Van Den Berg, David J;
  • Hutter, Carolyn M;
  • Aragaki, Aaron K;
  • Butterbach, Katja;
  • Caan, Bette J;
  • Carlson, Christopher S;
  • Chanock, Stephen J;
  • Curtis, Keith R;
  • Fuchs, Charles S;
  • Gala, Manish;
  • Giovannucci, Edward L;
  • Gogarten, Stephanie M;
  • Hayes, Richard B;
  • Henderson, Brian;
  • Hunter, David J;
  • Jackson, Rebecca D;
  • Kolonel, Laurence N;
  • Kooperberg, Charles;
  • Küry, Sébastien;
  • LaCroix, Andrea;
  • Laurie, Cathy C;
  • Laurie, Cecelia A;
  • Lemire, Mathieu;
  • Levine, David;
  • Ma, Jing;
  • Makar, Karen W;
  • Qu, Conghui;
  • Taverna, Darin;
  • Ulrich, Cornelia M;
  • Wu, Kana;
  • Kono, Suminori;
  • West, Dee W;
  • Berndt, Sonja I;
  • Bezieau, Stéphane;
  • Brenner, Hermann;
  • Campbell, Peter T;
  • Chan, Andrew T;
  • Chang-Claude, Jenny;
  • Coetzee, Gerhard A;
  • Conti, David V;
  • Duggan, David;
  • Figueiredo, Jane C;
  • Fortini, Barbara K;
  • Gallinger, Steven J;
  • Gauderman, W James;
  • Giles, Graham;
  • Green, Roger;
  • Haile, Robert;
  • Harrison, Tabitha A;
  • Hoffmeister, Michael;
  • Hopper, John L;
  • Hudson, Thomas J;
  • Hudson, Thomas J;
  • Jacobs, Eric;
  • Jacobs, Eric;
  • Iwasaki, Motoki;
  • Jee, Sun Ha;
  • Jenkins, Mark;
  • Jia, Wei-Hua;
  • Joshi, Amit;
  • Li, Li;
  • Lindor, Noralene M;
  • Matsuo, Keitaro;
  • Moreno, Victor;
  • Mukherjee, Bhramar;
  • Newcomb, Polly A;
  • Potter, John D;
  • Potter, John D;
  • Raskin, Leon;
  • Rennert, Gad;
  • Rosse, Stephanie;
  • Severi, Gianluca;
  • Schoen, Robert E;
  • Seminara, Daniela;
  • Shu, Xiao-Ou;
  • Slattery, Martha L;
  • Tsugane, Shoichiro;
  • White, Emily;
  • Xiang, Yong-Bing;
  • Zanke, Brent W;
  • Zheng, Wei;
  • Le Marchand, Loic;
  • Casey, Graham;
  • Gruber, Stephen B;
  • Peters, Ulrike
  • et al.

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Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

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