Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
- Author(s): Schumacher, Fredrick R;
- Schmit, Stephanie L;
- Jiao, Shuo;
- Edlund, Christopher K;
- Wang, Hansong;
- Zhang, Ben;
- Hsu, Li;
- Huang, Shu-Chen;
- Fischer, Christopher P;
- Harju, John F;
- Idos, Gregory E;
- Lejbkowicz, Flavio;
- Manion, Frank J;
- McDonnell, Kevin;
- McNeil, Caroline E;
- Melas, Marilena;
- Rennert, Hedy S;
- Shi, Wei;
- Thomas, Duncan C;
- Van Den Berg, David J;
- Hutter, Carolyn M;
- Aragaki, Aaron K;
- Butterbach, Katja;
- Caan, Bette J;
- Carlson, Christopher S;
- Chanock, Stephen J;
- Curtis, Keith R;
- Fuchs, Charles S;
- Gala, Manish;
- Giovannucci, Edward L;
- Gogarten, Stephanie M;
- Hayes, Richard B;
- Henderson, Brian;
- Hunter, David J;
- Jackson, Rebecca D;
- Kolonel, Laurence N;
- Kooperberg, Charles;
- Küry, Sébastien;
- LaCroix, Andrea;
- Laurie, Cathy C;
- Laurie, Cecelia A;
- Lemire, Mathieu;
- Levine, David;
- Ma, Jing;
- Makar, Karen W;
- Qu, Conghui;
- Taverna, Darin;
- Ulrich, Cornelia M;
- Wu, Kana;
- Kono, Suminori;
- West, Dee W;
- Berndt, Sonja I;
- Bezieau, Stéphane;
- Brenner, Hermann;
- Campbell, Peter T;
- Chan, Andrew T;
- Chang-Claude, Jenny;
- Coetzee, Gerhard A;
- Conti, David V;
- Duggan, David;
- Figueiredo, Jane C;
- Fortini, Barbara K;
- Gallinger, Steven J;
- Gauderman, W James;
- Giles, Graham;
- Green, Roger;
- Haile, Robert;
- Harrison, Tabitha A;
- Hoffmeister, Michael;
- Hopper, John L;
- Hudson, Thomas J;
- Hudson, Thomas J;
- Jacobs, Eric;
- Jacobs, Eric;
- Iwasaki, Motoki;
- Jee, Sun Ha;
- Jenkins, Mark;
- Jia, Wei-Hua;
- Joshi, Amit;
- Li, Li;
- Lindor, Noralene M;
- Matsuo, Keitaro;
- Moreno, Victor;
- Mukherjee, Bhramar;
- Newcomb, Polly A;
- Potter, John D;
- Potter, John D;
- Raskin, Leon;
- Rennert, Gad;
- Rosse, Stephanie;
- Severi, Gianluca;
- Schoen, Robert E;
- Seminara, Daniela;
- Shu, Xiao-Ou;
- Slattery, Martha L;
- Tsugane, Shoichiro;
- White, Emily;
- Xiang, Yong-Bing;
- Zanke, Brent W;
- Zheng, Wei;
- Le Marchand, Loic;
- Casey, Graham;
- Gruber, Stephen B;
- Peters, Ulrike
- et al.
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967357/Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
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