Genome-wide association study of colorectal cancer identifies six new susceptibility loci
- Author(s): Schumacher, Fredrick R
- Schmit, Stephanie L
- Jiao, Shuo
- Edlund, Christopher K
- Wang, Hansong
- Zhang, Ben
- Hsu, Li
- Huang, Shu-Chen
- Fischer, Christopher P
- Harju, John F
- Idos, Gregory E
- Lejbkowicz, Flavio
- Manion, Frank J
- McDonnell, Kevin
- McNeil, Caroline E
- Melas, Marilena
- Rennert, Hedy S
- Shi, Wei
- Thomas, Duncan C
- Van Den Berg, David J
- Hutter, Carolyn M
- Aragaki, Aaron K
- Butterbach, Katja
- Caan, Bette J
- Carlson, Christopher S
- Chanock, Stephen J
- Curtis, Keith R
- Fuchs, Charles S
- Gala, Manish
- Giovannucci, Edward L
- Gogarten, Stephanie M
- Hayes, Richard B
- Henderson, Brian
- Hunter, David J
- Jackson, Rebecca D
- Kolonel, Laurence N
- Kooperberg, Charles
- Küry, Sébastien
- LaCroix, Andrea
- Laurie, Cathy C
- Laurie, Cecelia A
- Lemire, Mathieu
- Levine, David
- Ma, Jing
- Makar, Karen W
- Qu, Conghui
- Taverna, Darin
- Ulrich, Cornelia M
- Wu, Kana
- Kono, Suminori
- West, Dee W
- Berndt, Sonja I
- Bezieau, Stéphane
- Brenner, Hermann
- Campbell, Peter T
- Chan, Andrew T
- Chang-Claude, Jenny
- Coetzee, Gerhard A
- Conti, David V
- Duggan, David
- Figueiredo, Jane C
- Fortini, Barbara K
- Gallinger, Steven J
- Gauderman, W James
- Giles, Graham
- Green, Roger
- Haile, Robert
- Harrison, Tabitha A
- Hoffmeister, Michael
- Hopper, John L
- Hudson, Thomas J
- Jacobs, Eric
- Iwasaki, Motoki
- Jee, Sun Ha
- Jenkins, Mark
- Jia, Wei-Hua
- Joshi, Amit
- Li, Li
- Lindor, Noralene M
- Matsuo, Keitaro
- Moreno, Victor
- Mukherjee, Bhramar
- Newcomb, Polly A
- Potter, John D
- Raskin, Leon
- Rennert, Gad
- Rosse, Stephanie
- Severi, Gianluca
- Schoen, Robert E
- Seminara, Daniela
- Shu, Xiao-Ou
- Slattery, Martha L
- Tsugane, Shoichiro
- White, Emily
- Xiang, Yong-Bing
- Zanke, Brent W
- Zheng, Wei
- Le Marchand, Loic
- Casey, Graham
- Gruber, Stephen B
- Peters, Ulrike
- et al.
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967357/Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
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