Preterm infant with a late presentation of blueberry muffin lesions secondary to recombinant erythropoietin
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Preterm infant with a late presentation of blueberry muffin lesions secondary to recombinant erythropoietin

  • Author(s): Rajpara, Anand
  • Blackmon, Joseph
  • Laarman, Rachel
  • Skaggs, Robert
  • Liolios, Ana
  • Lui, Deede
  • Fraga, Garth
  • et al.
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License
Abstract

Our patient is a 26-week-old preterm female infant delivered by caesarean section secondary to severe maternal preeclampsia who had been receiving subcutaneous recombinant erythropoietin (r-EPO) for anemia of prematurity. At 8 weeks of age after 8 doses of r-EPO, the infant developed numerous non-blanching erythematous macules and patches located on the back, posterior shoulder, and posterior arms, concerning for late-onset blueberry muffin lesions. Biopsy of the lesions confirmed dermal hematopoiesis. After r-EPO was discontinued all skin lesions gradually resolved over a period of 2 weeks and never recurred. 

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