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Adult height is associated with increased risk of ovarian cancer: A Mendelian randomisation study

  • Author(s): Dixon-Suen, SC
  • Nagle, CM
  • Thrift, AP
  • Pharoah, PDP
  • Ewing, A
  • Pearce, CL
  • Zheng, W
  • Chenevix-Trench, G
  • Fasching, PA
  • Beckmann, MW
  • Lambrechts, D
  • Vergote, I
  • Lambrechts, S
  • Van Nieuwenhuysen, E
  • Rossing, MA
  • Doherty, JA
  • Wicklund, KG
  • Chang-Claude, J
  • Jung, AY
  • Moysich, KB
  • Odunsi, K
  • Goodman, MT
  • Wilkens, LR
  • Thompson, PJ
  • Shvetsov, YB
  • Dörk, T
  • Park-Simon, TW
  • Hillemanns, P
  • Bogdanova, N
  • Butzow, R
  • Nevanlinna, H
  • Pelttari, LM
  • Leminen, A
  • Modugno, F
  • Ness, RB
  • Edwards, RP
  • Kelley, JL
  • Heitz, F
  • Du Bois, A
  • Harter, P
  • Schwaab, I
  • Karlan, BY
  • Lester, J
  • Orsulic, S
  • Rimel, BJ
  • Kjær, SK
  • Høgdall, E
  • Jensen, A
  • Goode, EL
  • Fridley, BL
  • Cunningham, JM
  • Winham, SJ
  • Giles, GG
  • Bruinsma, F
  • Milne, RL
  • Southey, MC
  • Hildebrandt, MAT
  • Wu, X
  • Lu, KH
  • Liang, D
  • Levine, DA
  • Bisogna, M
  • Schildkraut, JM
  • Berchuck, A
  • Cramer, DW
  • Terry, KL
  • Bandera, EV
  • Olson, SH
  • Salvesen, HB
  • Thomsen, LCV
  • Kopperud, RK
  • Bjorge, L
  • Kiemeney, LA
  • Massuger, LFAG
  • Pejovic, T
  • et al.

Published Web Location

https://www.nature.com/articles/s41416-018-0011-3.pdf
No data is associated with this publication.
Abstract

© 2018 Cancer Research UK. Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Results: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. Conclusions: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

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