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Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study
- Dixon-Suen, Suzanne C;
- Nagle, Christina M;
- Thrift, Aaron P;
- Pharoah, Paul DP;
- Ewing, Ailith;
- Pearce, Celeste Leigh;
- Zheng, Wei;
- Australian Ovarian Cancer Study Group;
- Chenevix-Trench, Georgia;
- Fasching, Peter A;
- Beckmann, Matthias W;
- Lambrechts, Diether;
- Vergote, Ignace;
- Lambrechts, Sandrina;
- Van Nieuwenhuysen, Els;
- Rossing, Mary Anne;
- Doherty, Jennifer A;
- Wicklund, Kristine G;
- Chang-Claude, Jenny;
- Jung, Audrey Y;
- Moysich, Kirsten B;
- Odunsi, Kunle;
- Goodman, Marc T;
- Wilkens, Lynne R;
- Thompson, Pamela J;
- Shvetsov, Yurii B;
- Dörk, Thilo;
- Park-Simon, Tjoung-Won;
- Hillemanns, Peter;
- Bogdanova, Natalia;
- Butzow, Ralf;
- Nevanlinna, Heli;
- Pelttari, Liisa M;
- Leminen, Arto;
- Modugno, Francesmary;
- Ness, Roberta B;
- Edwards, Robert P;
- Kelley, Joseph L;
- Heitz, Florian;
- du Bois, Andreas;
- Harter, Philipp;
- Schwaab, Ira;
- Karlan, Beth Y;
- Lester, Jenny;
- Orsulic, Sandra;
- Rimel, Bobbie J;
- Kjær, Susanne K;
- Høgdall, Estrid;
- Jensen, Allan;
- Goode, Ellen L;
- Fridley, Brooke L;
- Cunningham, Julie M;
- Winham, Stacey J;
- Giles, Graham G;
- Bruinsma, Fiona;
- Milne, Roger L;
- Southey, Melissa C;
- Hildebrandt, Michelle AT;
- Wu, Xifeng;
- Lu, Karen H;
- Liang, Dong;
- Levine, Douglas A;
- Bisogna, Maria;
- Schildkraut, Joellen M;
- Berchuck, Andrew;
- Cramer, Daniel W;
- Terry, Kathryn L;
- Bandera, Elisa V;
- Olson, Sara H;
- Salvesen, Helga B;
- Thomsen, Liv Cecilie Vestrheim;
- Kopperud, Reidun K;
- Bjorge, Line;
- Kiemeney, Lambertus A;
- Massuger, Leon FAG;
- Pejovic, Tanja;
- Bruegl, Amanda;
- Cook, Linda S;
- Le, Nhu D;
- Swenerton, Kenneth D;
- Brooks-Wilson, Angela;
- Kelemen, Linda E;
- Lubiński, Jan;
- Huzarski, Tomasz;
- Gronwald, Jacek;
- Menkiszak, Janusz;
- Wentzensen, Nicolas;
- Brinton, Louise;
- Yang, Hannah;
- Lissowska, Jolanta;
- Høgdall, Claus K;
- Lundvall, Lene;
- Song, Honglin;
- Tyrer, Jonathan P;
- Campbell, Ian;
- Eccles, Diana;
- Paul, James;
- Glasspool, Rosalind;
- Siddiqui, Nadeem;
- Whittemore, Alice S;
- Sieh, Weiva;
- McGuire, Valerie;
- Rothstein, Joseph H;
- Narod, Steven A;
- Phelan, Catherine;
- Risch, Harvey A;
- McLaughlin, John R;
- Anton-Culver, Hoda;
- Ziogas, Argyrios;
- Menon, Usha;
- Gayther, Simon A;
- Ramus, Susan J;
- Gentry-Maharaj, Aleksandra;
- Wu, Anna H;
- Pike, Malcolm C;
- Tseng, Chiu-Chen;
- Kupryjanczyk, Jolanta;
- Dansonka-Mieszkowska, Agnieszka;
- Budzilowska, Agnieszka;
- Rzepecka, Iwona K;
- Webb, Penelope M;
- on behalf of the Ovarian Cancer Association Consortium
- et al.
Published Web Location
https://www.nature.com/articles/s41416-018-0011-3.pdfNo data is associated with this publication.
Abstract
Background
Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.Methods
We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.Results
Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.Conclusions
Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.