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Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

  • Author(s): Dixon-Suen, Suzanne C
  • Nagle, Christina M
  • Thrift, Aaron P
  • Pharoah, Paul DP
  • Ewing, Ailith
  • Pearce, Celeste Leigh
  • Zheng, Wei
  • Australian Ovarian Cancer Study Group
  • Chenevix-Trench, Georgia
  • Fasching, Peter A
  • Beckmann, Matthias W
  • Lambrechts, Diether
  • Vergote, Ignace
  • Lambrechts, Sandrina
  • Van Nieuwenhuysen, Els
  • Rossing, Mary Anne
  • Doherty, Jennifer A
  • Wicklund, Kristine G
  • Chang-Claude, Jenny
  • Jung, Audrey Y
  • Moysich, Kirsten B
  • Odunsi, Kunle
  • Goodman, Marc T
  • Wilkens, Lynne R
  • Thompson, Pamela J
  • Shvetsov, Yurii B
  • Dörk, Thilo
  • Park-Simon, Tjoung-Won
  • Hillemanns, Peter
  • Bogdanova, Natalia
  • Butzow, Ralf
  • Nevanlinna, Heli
  • Pelttari, Liisa M
  • Leminen, Arto
  • Modugno, Francesmary
  • Ness, Roberta B
  • Edwards, Robert P
  • Kelley, Joseph L
  • Heitz, Florian
  • du Bois, Andreas
  • Harter, Philipp
  • Schwaab, Ira
  • Karlan, Beth Y
  • Lester, Jenny
  • Orsulic, Sandra
  • Rimel, Bobbie J
  • Kjær, Susanne K
  • Høgdall, Estrid
  • Jensen, Allan
  • Goode, Ellen L
  • Fridley, Brooke L
  • Cunningham, Julie M
  • Winham, Stacey J
  • Giles, Graham G
  • Bruinsma, Fiona
  • Milne, Roger L
  • Southey, Melissa C
  • Hildebrandt, Michelle AT
  • Wu, Xifeng
  • Lu, Karen H
  • Liang, Dong
  • Levine, Douglas A
  • Bisogna, Maria
  • Schildkraut, Joellen M
  • Berchuck, Andrew
  • Cramer, Daniel W
  • Terry, Kathryn L
  • Bandera, Elisa V
  • Olson, Sara H
  • Salvesen, Helga B
  • Thomsen, Liv Cecilie Vestrheim
  • Kopperud, Reidun K
  • Bjorge, Line
  • Kiemeney, Lambertus A
  • Massuger, Leon FAG
  • Pejovic, Tanja
  • Bruegl, Amanda
  • Cook, Linda S
  • Le, Nhu D
  • Swenerton, Kenneth D
  • Brooks-Wilson, Angela
  • Kelemen, Linda E
  • Lubiński, Jan
  • Huzarski, Tomasz
  • Gronwald, Jacek
  • Menkiszak, Janusz
  • Wentzensen, Nicolas
  • Brinton, Louise
  • Yang, Hannah
  • Lissowska, Jolanta
  • Høgdall, Claus K
  • Lundvall, Lene
  • Song, Honglin
  • Tyrer, Jonathan P
  • Campbell, Ian
  • Eccles, Diana
  • Paul, James
  • Glasspool, Rosalind
  • Siddiqui, Nadeem
  • Whittemore, Alice S
  • Sieh, Weiva
  • McGuire, Valerie
  • Rothstein, Joseph H
  • Narod, Steven A
  • Phelan, Catherine
  • Risch, Harvey A
  • McLaughlin, John R
  • Anton-Culver, Hoda
  • Ziogas, Argyrios
  • Menon, Usha
  • Gayther, Simon A
  • Ramus, Susan J
  • Gentry-Maharaj, Aleksandra
  • Wu, Anna H
  • Pike, Malcolm C
  • Tseng, Chiu-Chen
  • Kupryjanczyk, Jolanta
  • Dansonka-Mieszkowska, Agnieszka
  • Budzilowska, Agnieszka
  • Rzepecka, Iwona K
  • Webb, Penelope M
  • Ovarian Cancer Association Consortium
  • et al.

Published Web Location

https://www.nature.com/articles/s41416-018-0011-3.pdf
No data is associated with this publication.
Abstract

Background

Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.

Methods

We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.

Results

Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.

Conclusions

Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

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