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Multisite phosphorylation networks as signal processors for Cdk1
- Kõivomägi, Mardo;
- Örd, Mihkel;
- Iofik, Anna;
- Valk, Ervin;
- Venta, Rainis;
- Faustova, Ilona;
- Kivi, Rait;
- Balog, Eva Rose M;
- Rubin, Seth M;
- Loog, Mart
Published Web Location
https://doi.org/10.1038/nsmb.2706Abstract
Selective protein phosphorylation in a time-resolved manner is essential to an ordered progression through the cell cycle. A new study now shows how the phopshoadaptor protein Cks1 acts as a signal processor for Cdk1 by regulating the differential amplification of multiple phosphorylation events to generate a wide range of thresholds during the cell cycle.
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