Mouse models address key concerns regarding autophagy inhibition in cancer therapy
- Author(s): Amaravadi, R
- Debnath, J
- et al.
Published Web Locationhttps://doi.org/10.1158/2159-8290.CD-14-0618
With multiple clinical trials under way targeting autophagy against cancer, Yang and colleagues and Karsli-Uzunbas and colleagues address important concerns regarding autophagy inhibition in patients with cancer, using genetically engineered mouse models that more accurately represent the tumor biology found in human patients with pancreatic and lung cancers. © 2014 American Association for Cancer Research.
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