Skip to main content
Download PDF
- Main
External Beam Radiation Therapy or Brachytherapy With or Without Short-course Neoadjuvant Androgen Deprivation Therapy: Results of a Multicenter, Prospective Study of Quality of Life
- Gay, Hiram A;
- Sanda, Martin G;
- Liu, Jingxia;
- Wu, Ningying;
- Hamstra, Daniel A;
- Wei, John T;
- Dunn, Rodney L;
- Klein, Eric A;
- Sandler, Howard M;
- Saigal, Christopher S;
- Litwin, Mark S;
- Kuban, Deborah A;
- Hembroff, Larry;
- Regan, Meredith M;
- Chang, Peter;
- Consortium, Prostate Cancer Outcomes and Satisfaction with Treatment Quality Assessment;
- Regan, Meredith;
- Hembroff, Larry;
- Wei, John T;
- Hamstra, Dan;
- Dunn, Rodney;
- Northouse, Laurel;
- Wood, David;
- Klein, Eric A;
- Ciezki, Jay;
- Michalski, Jeff;
- Andriole, Gerald;
- Litwin, Mark S;
- Saigal, Christopher;
- Greenfield, Thomas;
- Pisters, Louis;
- Kuban, Deborah;
- Sandler, Howard;
- Hu, Jim;
- Kibel, Adam;
- Dahl, Douglas;
- Zietman, Anthony;
- Chang, Peter;
- Kaplan, Irving;
- Wagner, Andrew;
- Sanda, Martin G;
- Michalski, Jeff M
- et al.
Published Web Location
https://doi.org/10.1016/j.ijrobp.2017.02.019Abstract
Purpose
The long-term effects of neoadjuvant androgen deprivation therapy (NADT) with radiation therapy on participant-reported health-related quality of life (HRQOL) have not been characterized in prospective multicenter studies. We evaluated HRQOL for 2 years among participants undergoing radiation therapy (RT) with or without NADT for newly diagnosed, early-stage prostate cancer.Methods and materials
We analyzed longitudinal cohort data from the Prostate Cancer Outcomes and Satisfaction with Treatment Quality Assessment Consortium to ascertain the HRQOL trajectory of men receiving NADT with external beam RT (EBRT) or brachytherapy. HRQOL was measured using the expanded prostate cancer index composite 26-item questionnaire at 2, 6, 12, and 24 months after the initiation of NADT. We used the χ2 or Fisher exact test to compare the shift in percentages between groups that did or did not receive NADT. Analyses were conducted at the 2-sided 5% significance level.Results
For subjects receiving EBRT, questions regarding the ability to have an erection, ability to reach an orgasm, quality of erections, frequency of erections, ability to function sexually, and lack of energy were in a significantly worse dichotomized category for the patients receiving NADT. Comparing the baseline versus 24-month outcomes, 24%, 23%, and 30% of participants receiving EBRT plus NADT shifted to the worse dichotomized category for the ability to reach an orgasm, quality of erections, and ability to function sexually compared with 14%, 13%, and 16% in the EBRT group, respectively.Conclusions
Compared with baseline, at 2 years, participants receiving NADT plus EBRT compared with EBRT alone had worse HRQOL, as measured by the ability to reach orgasm, quality of erections, and ability to function sexually. However, no difference was found in the ability to have an erection, frequency of erections, overall sexual function, hot flashes, breast tenderness/enlargement, depression, lack of energy, or change in body weight. The improved survival in intermediate- and high-risk patients receiving NADT and EBRT necessitates pretreatment counseling of the HRQOL effect of NADT and EBRT.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%