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Constrained bithiazoles: Small molecule correctors of defective δf508-CFTR protein trafficking

  • Author(s): Verkman, Alan
  • Coffman, KC
  • Nguyen, HH
  • Phuan, PW
  • Hudson, BM
  • Yu, GJ
  • Bagdasarian, AL
  • Montgomery, D
  • Lodewyk, MW
  • Yang, B
  • Yoo, CL
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4136667?pdf=render
No data is associated with this publication.
Abstract

Conformationally constrained bithiazoles were previously found to have improved efficacy over nonconstrained bithiazoles for correction of defective cellular processing of the δF508 mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein.

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