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Constrained bithiazoles: Small molecule correctors of defective δf508-CFTR protein trafficking

Published Web Location

http://europepmc.org/articles/PMC4136667?pdf=render
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Abstract

Conformationally constrained bithiazoles were previously found to have improved efficacy over nonconstrained bithiazoles for correction of defective cellular processing of the δF508 mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein.

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