School of Medicine
Unilateral hypoxic brain perfusion for generation of cerebral ischemic injury in rat.
- Author(s): Navarro, Roman
- et al.
Unilateral hypoxic ischemia via common carotid artery infusion was not achieved. Despite evidence of hippocampal necrosis as indicated by Fluoro-Jade immunohistochemistry, animals displayed no qualitative neurological deficits. It is likely that intra-ischemic systemic and intracranial hypothermia created a neuroprotective environment during infusion. Further studies will necessitate sufficient temperature control based on intracranial temperatures.