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Open Access Publications from the University of California

Unilateral hypoxic brain perfusion for generation of cerebral ischemic injury in rat.

  • Author(s): Navarro, Roman
  • et al.

Unilateral hypoxic ischemia via common carotid artery infusion was not achieved. Despite evidence of hippocampal necrosis as indicated by Fluoro-Jade immunohistochemistry, animals displayed no qualitative neurological deficits. It is likely that intra-ischemic systemic and intracranial hypothermia created a neuroprotective environment during infusion. Further studies will necessitate sufficient temperature control based on intracranial temperatures.

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