Skip to main content
Open Access Publications from the University of California


UCLA Previously Published Works bannerUCLA

Older age predicts short-term, serious events after syncope.

  • Author(s): Sun, Benjamin C
  • Hoffman, Jerome R
  • Mangione, Carol M
  • Mower, William R
  • et al.


To assess the relationship between age and 14-day serious events after an emergency department (ED) visit for syncope.


One-year prospective cohort study.


Single academic ED.


Adult patients with an ED complaint of syncope or near-syncope.


Treating physicians prospectively recorded the presence or absence of potential risk factors for serious clinical events. Patients were contacted by telephone at 14 days for a structured interview. A three-physician panel reviewed ED charts, hospital records, and telephone interview forms to identify predefined events. The primary outcome included any 14-day predefined event. A secondary outcome included any 14-day predefined event that was first diagnosed after the initial ED visit. Age was analyzed in 20-year intervals. Multivariate logistic regression controlled for baseline demographic, comorbidity, and electrocardiogram data.


Of 592 eligible patients, 477 (81%) provided informed consent. Follow-up was successfully obtained for 463 (97%) patients. The age range was 18 to 96, and 47% of patients were aged 60 and older. There were 80 (17%) patients who had a 14-day event, including 18 (4%) with a delayed diagnosis. Compared with patients aged 18 to 39, the adjusted odds ratio (OR) of a serious outcome was 2.7 (95% confidence interval (CI)=0.9-8.4) for patient aged 40 to 59, 3.8 (95% CI=1.3-12) for patients aged 60 to 79, and 3.8 (95% CI=1.2-12) for patients aged 80 and older.


Age of 60 and older is strongly associated with short-term serious events after an ED visit for syncope.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View