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Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
Published Web Location
http://europepmc.org/articles/PMC4128640?pdf=renderNo data is associated with this publication.
Abstract
'Pre-leukaemic' mutations are thought to promote clonal expansion of haematopoietic stem cells (HSCs) by increasing self-renewal and competitiveness; however, mutations that increase HSC proliferation tend to reduce competitiveness and self-renewal potenti
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