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Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women.

  • Author(s): Koss, Catherine A
  • Natureeba, Paul
  • Nyafwono, Dorcas
  • Plenty, Albert
  • Mwesigwa, Julia
  • Nzarubara, Bridget
  • Clark, Tamara D
  • Ruel, Theodore D
  • Achan, Jane
  • Charlebois, Edwin D
  • Cohan, Deborah
  • Kamya, Moses R
  • Havlir, Diane V
  • Young, Sera L
  • et al.
Abstract

Food insecurity is associated with poor virologic outcomes, but this has not been studied during pregnancy and breastfeeding. We assessed sustained viral suppression from 8 weeks on antiretroviral therapy to 48 weeks postpartum among 171 pregnant and breastfeeding Ugandan women; 74.9% experienced food insufficiency. In multivariable analysis, food insufficiency [adjusted odds ratio (aOR) 0.38, 95% confidence interval (CI): 0.16 to 0.91], higher pretreatment HIV-1 RNA (aOR 0.55 per 10-fold increase, 95% CI: 0.37 to 0.82), and lopinavir/ritonavir versus efavirenz (aOR 0.49, 95% CI: 0.24 to 0.96) were associated with lower odds of sustained viral suppression. Interventions to address food security may improve virologic outcomes among HIV-infected women.

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