Variability in viral pathogenesis: modeling the dynamic of acute and persistent infections.
Published Web Locationhttps://doi.org/10.1016/j.coviro.2017.05.001
Virus infection often results in diverse outcomes. This variability of virus pathogenesis is not well understood. Here we revise theoretical arguments to further our understanding of factors controlling infection and its severity. We propose that variability in these factors results in different clinical outcomes, which ultimately ensure virus reproduction.