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Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

  • Author(s): Boxer, Adam
  • Miller, Bruce
  • Seeley, William
  • Almeida, S
  • Gascon, E
  • Tran, H
  • Chou, HJ
  • Gendron, TF
  • Degroot, S
  • Tapper, AR
  • Sellier, C
  • Charlet-Berguerand, N
  • Karydas, A
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3753484?pdf=render
No data is associated with this publication.
Abstract

The recently identified GGGGCC repeat expansion in the noncoding region of C9ORF72 is the most common pathogenic mutation in patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). We generated a human neuronal model and investi

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