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Peripheral gating of pain signals by endogenous lipid mediators

Published Web Location

https://doi.org/10.1038/nn.3612
Abstract

In this Review, Piomelli and Sasso survey the functions of endogenous lipid mediators in the peripheral gating of nociceptive signals. They focus on the mechanisms and pathways associated with analgesic lipids, such as endocannabinoids, lipid amides, lipoxins and resolvins, and discuss their role in the interaction between nociceptive and immune systems in the context of pain.

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