MicroRNAs in B cell development and malignancy
- Author(s): Fernando, Thilini R
- Rodriguez-Malave, Norma I
- Rao, Dinesh S
- et al.
Published Web Locationhttp://dx.doi.org/10.1186/1756-8722-5-7
Abstract MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and is also critical at the level of specific miRNAs. In this review, we discuss miRNAs that are involved in normal B cell development in the bone marrow and during B cell activation and terminal differentiation in the periphery. Next, we turn to miRNAs that are dysregulated during diseases of B cells, including malignant diseases and autoimmunity. Further study of miRNAs and their targets will lead to a better understanding of B cell development, and should also lead to the development of novel therapeutic strategies against B cell diseases.
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