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A genome-wide association study of marginal zone lymphoma shows association to the HLA region.

  • Author(s): Vijai, Joseph
  • Wang, Zhaoming
  • Berndt, Sonja I
  • Skibola, Christine F
  • Slager, Susan L
  • de Sanjose, Silvia
  • Melbye, Mads
  • Glimelius, Bengt
  • Bracci, Paige M
  • Conde, Lucia
  • Birmann, Brenda M
  • Wang, Sophia S
  • Brooks-Wilson, Angela R
  • Lan, Qing
  • de Bakker, Paul IW
  • Vermeulen, Roel CH
  • Portlock, Carol
  • Ansell, Stephen M
  • Link, Brian K
  • Riby, Jacques
  • North, Kari E
  • Gu, Jian
  • Hjalgrim, Henrik
  • Cozen, Wendy
  • Becker, Nikolaus
  • Teras, Lauren R
  • Spinelli, John J
  • Turner, Jenny
  • Zhang, Yawei
  • Purdue, Mark P
  • Giles, Graham G
  • Kelly, Rachel S
  • Zeleniuch-Jacquotte, Anne
  • Ennas, Maria Grazia
  • Monnereau, Alain
  • Bertrand, Kimberly A
  • Albanes, Demetrius
  • Lightfoot, Tracy
  • Yeager, Meredith
  • Chung, Charles C
  • Burdett, Laurie
  • Hutchinson, Amy
  • Lawrence, Charles
  • Montalvan, Rebecca
  • Liang, Liming
  • Huang, Jinyan
  • Ma, Baoshan
  • Villano, Danylo J
  • Maria, Ann
  • Corines, Marina
  • Thomas, Tinu
  • Novak, Anne J
  • Dogan, Ahmet
  • Liebow, Mark
  • Thompson, Carrie A
  • Witzig, Thomas E
  • Habermann, Thomas M
  • Weiner, George J
  • Smith, Martyn T
  • Holly, Elizabeth A
  • Jackson, Rebecca D
  • Tinker, Lesley F
  • Ye, Yuanqing
  • Adami, Hans-Olov
  • Smedby, Karin E
  • De Roos, Anneclaire J
  • Hartge, Patricia
  • Morton, Lindsay M
  • Severson, Richard K
  • Benavente, Yolanda
  • Boffetta, Paolo
  • Brennan, Paul
  • Foretova, Lenka
  • Maynadie, Marc
  • McKay, James
  • Staines, Anthony
  • Diver, W Ryan
  • Vajdic, Claire M
  • Armstrong, Bruce K
  • Kricker, Anne
  • Zheng, Tongzhang
  • Holford, Theodore R
  • Severi, Gianluca
  • Vineis, Paolo
  • Ferri, Giovanni M
  • Ricco, Rosalia
  • Miligi, Lucia
  • Clavel, Jacqueline
  • Giovannucci, Edward
  • Kraft, Peter
  • Virtamo, Jarmo
  • Smith, Alex
  • Kane, Eleanor
  • Roman, Eve
  • Chiu, Brian CH
  • Fraumeni, Joseph F
  • Wu, Xifeng
  • Cerhan, James R
  • Offit, Kenneth
  • Chanock, Stephen J
  • Rothman, Nathaniel
  • Nieters, Alexandra
  • et al.
Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

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