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A genome-wide association study of marginal zone lymphoma shows association to the HLA region
- Vijai, Joseph;
- Wang, Zhaoming;
- Berndt, Sonja I;
- Skibola, Christine F;
- Slager, Susan L;
- de Sanjose, Silvia;
- Melbye, Mads;
- Glimelius, Bengt;
- Bracci, Paige M;
- Conde, Lucia;
- Birmann, Brenda M;
- Wang, Sophia S;
- Brooks-Wilson, Angela R;
- Lan, Qing;
- de Bakker, Paul IW;
- Vermeulen, Roel CH;
- Portlock, Carol;
- Ansell, Stephen M;
- Link, Brian K;
- Riby, Jacques;
- North, Kari E;
- Gu, Jian;
- Hjalgrim, Henrik;
- Cozen, Wendy;
- Becker, Nikolaus;
- Teras, Lauren R;
- Spinelli, John J;
- Turner, Jenny;
- Zhang, Yawei;
- Purdue, Mark P;
- Giles, Graham G;
- Kelly, Rachel S;
- Zeleniuch-Jacquotte, Anne;
- Ennas, Maria Grazia;
- Monnereau, Alain;
- Bertrand, Kimberly A;
- Albanes, Demetrius;
- Lightfoot, Tracy;
- Yeager, Meredith;
- Chung, Charles C;
- Burdett, Laurie;
- Hutchinson, Amy;
- Lawrence, Charles;
- Montalvan, Rebecca;
- Liang, Liming;
- Huang, Jinyan;
- Ma, Baoshan;
- Villano, Danylo J;
- Maria, Ann;
- Corines, Marina;
- Thomas, Tinu;
- Novak, Anne J;
- Dogan, Ahmet;
- Liebow, Mark;
- Thompson, Carrie A;
- Witzig, Thomas E;
- Habermann, Thomas M;
- Weiner, George J;
- Smith, Martyn T;
- Holly, Elizabeth A;
- Jackson, Rebecca D;
- Tinker, Lesley F;
- Ye, Yuanqing;
- Adami, Hans-Olov;
- Smedby, Karin E;
- De Roos, Anneclaire J;
- Hartge, Patricia;
- Morton, Lindsay M;
- Severson, Richard K;
- Benavente, Yolanda;
- Boffetta, Paolo;
- Brennan, Paul;
- Foretova, Lenka;
- Maynadie, Marc;
- McKay, James;
- Staines, Anthony;
- Diver, W Ryan;
- Vajdic, Claire M;
- Armstrong, Bruce K;
- Kricker, Anne;
- Zheng, Tongzhang;
- Holford, Theodore R;
- Severi, Gianluca;
- Vineis, Paolo;
- Ferri, Giovanni M;
- Ricco, Rosalia;
- Miligi, Lucia;
- Clavel, Jacqueline;
- Giovannucci, Edward;
- Kraft, Peter;
- Virtamo, Jarmo;
- Smith, Alex;
- Kane, Eleanor;
- Roman, Eve;
- Chiu, Brian CH;
- Fraumeni, Joseph F;
- Wu, Xifeng;
- Cerhan, James R;
- Offit, Kenneth;
- Chanock, Stephen J;
- Rothman, Nathaniel;
- Nieters, Alexandra
- et al.
Published Web Location
https://doi.org/10.1038/ncomms6751Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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