Relaxin: Review of Biology and Potential Role in Treating Heart Failure
- Author(s): Teichman, Sam L.
- Unemori, Elaine
- Teerlink, John R.
- Cotter, Gad
- Metra, Marco
- et al.
Published Web Locationhttps://doi.org/10.1007/s11897-010-0010-z
Relaxin is a naturally occurring human peptide initially identified as a reproductive hormone. More recently, relaxin has been shown to play a key role in the maternal hemodynamic and renal adjustments that accommodate pregnancy. An understanding of these physiologic effects has led to the evaluation of relaxin as a pharmacologic agent for the treatment of patients with acute heart failure. Preliminary results have been encouraging. In addition, the other known biologic properties of relaxin, including anti-inflammatory effects, extracellular matrix remodeling effects, and angiogenic and anti-ischemic effects, all may play a role in potential benefits of relaxin therapy. Ongoing, large-scale clinical testing will provide additional insights into the potential role of relaxin in the treatment of heart failure.