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Identification of genes required for eye development by high-throughput screening of mouse knockouts.

  • Author(s): Moore, Bret A
  • Leonard, Brian C
  • Sebbag, Lionel
  • Edwards, Sydney G
  • Cooper, Ann
  • Imai, Denise M
  • Straiton, Ewan
  • Santos, Luis
  • Reilly, Christopher
  • Griffey, Stephen M
  • Bower, Lynette
  • Clary, David
  • Mason, Jeremy
  • Roux, Michel J
  • Meziane, Hamid
  • Herault, Yann
  • International Mouse Phenotyping Consortium
  • McKerlie, Colin
  • Flenniken, Ann M
  • Nutter, Lauryl MJ
  • Berberovic, Zorana
  • Owen, Celeste
  • Newbigging, Susan
  • Adissu, Hibret
  • Eskandarian, Mohammed
  • Hsu, Chih-Wei
  • Kalaga, Sowmya
  • Udensi, Uchechukwu
  • Asomugha, Chinwe
  • Bohat, Ritu
  • Gallegos, Juan J
  • Seavitt, John R
  • Heaney, Jason D
  • Beaudet, Arthur L
  • Dickinson, Mary E
  • Justice, Monica J
  • Philip, Vivek
  • Kumar, Vivek
  • Svenson, Karen L
  • Braun, Robert E
  • Wells, Sara
  • Cater, Heather
  • Stewart, Michelle
  • Clementson-Mobbs, Sharon
  • Joynson, Russell
  • Gao, Xiang
  • Suzuki, Tomohiro
  • Wakana, Shigeharu
  • Smedley, Damian
  • Seong, JK
  • Tocchini-Valentini, Glauco
  • Moore, Mark
  • Fletcher, Colin
  • Karp, Natasha
  • Ramirez-Solis, Ramiro
  • White, Jacqueline K
  • de Angelis, Martin Hrabe
  • Wurst, Wolfgang
  • Thomasy, Sara M
  • Flicek, Paul
  • Parkinson, Helen
  • Brown, Steve DM
  • Meehan, Terrence F
  • Nishina, Patsy M
  • Murray, Stephen A
  • Krebs, Mark P
  • Mallon, Ann-Marie
  • Lloyd, KC Kent
  • Murphy, Christopher J
  • Moshiri, Ala
  • et al.
Abstract

Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for every mouse gene. Of 4364 genes evaluated, 347 were identified to influence ocular phenotypes, 75% of which are entirely novel in ocular pathology. This discovery greatly increases the current number of genes known to contribute to ophthalmic disease, and it is likely that many of the genes will subsequently prove to be important in human ocular development and disease.

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