Concise synthesis of (+)-fastigiatine.
- Author(s): Samame, Renzo A;
- Owens, Christina M;
- Rychnovsky, Scott D
- et al.
Published Web Locationhttps://doi.org/10.1039/c5sc03262h
(+)-Fastigiatine was assembled in six steps from (R)-5-methylcyclohex-2-en-1-one. Intermolecular Diels-Alder reaction introduced most of the carbon atoms for the target. The two Boc-protected nitrogen atom building blocks were introduced by a Suzuki coupling and a cuprate addition. A biomimetic transannular Mannich reaction generated the two quaternary centers at a late stage. Each step builds core bonds, and combined with a minimalist protecting group strategy, this approach led to a very concise synthesis.