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Validation of a diagnostic microarray for human papillomavirus: coverage of 102 genotypes.

  • Author(s): Arron, Sarah Tuttleton
  • Skewes-Cox, Peter
  • Do, Phong H
  • Dybbro, Eric
  • Da Costa, Maria
  • Palefsky, Joel M
  • Derisi, Joseph L
  • et al.
Abstract

Papillomaviruses have been implicated in a variety of human diseases ranging from common warts to invasive carcinoma of the anogenital mucosa. Existing assays for genotyping human papillomavirus are restricted to a small number of types. Here, we present a comprehensive, accurate microarray strategy for detection and genotyping of 102 human papillomavirus types and validate its use in a panel of 91 anal swabs. This array has equal performance to traditional dot blot analysis with the benefits of added genotype coverage and the ability to calibrate readout over a range of sensitivity or specificity values.

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