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Genetic association analyses highlight biological pathways underlying mitral valve prolapse
- Dina, Christian;
- Bouatia-Naji, Nabila;
- Tucker, Nathan;
- Delling, Francesca N;
- Toomer, Katelynn;
- Durst, Ronen;
- Perrocheau, Maelle;
- Fernandez-Friera, Leticia;
- Solis, Jorge;
- Le Tourneau, Thierry;
- Chen, Ming-Huei;
- Probst, Vincent;
- Bosse, Yohan;
- Pibarot, Philippe;
- Zelenika, Diana;
- Lathrop, Mark;
- Hercberg, Serge;
- Roussel, Ronan;
- Benjamin, Emelia J;
- Bonnet, Fabrice;
- Lo, Su Hao;
- Dolmatova, Elena;
- Simonet, Floriane;
- Lecointe, Simon;
- Kyndt, Florence;
- Redon, Richard;
- Le Marec, Hervé;
- Froguel, Philippe;
- Ellinor, Patrick T;
- Vasan, Ramachandran S;
- Bruneval, Patrick;
- Markwald, Roger R;
- Norris, Russell A;
- Milan, David J;
- Slaugenhaupt, Susan A;
- Levine, Robert A;
- Schott, Jean-Jacques;
- Hagege, Albert A;
- Jeunemaitre, Xavier
Published Web Location
https://doi.org/10.1038/ng.3383Abstract
Christian Dina, Nabila Bouatia-Naji, Xavier Jeunemaitre and colleagues from the Leducq Transatlantic MITRAL Network report the results of a genome-wide association study of nonsyndromic mitral valve prolapse. They identify six susceptibility loci and provide functional evidence implicating LMCD1 and TNS1 as genes influencing mitral valve development.
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