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Copper regulates cyclic-AMP-dependent lipolysis
- Krishnamoorthy, Lakshmi;
- Cotruvo, Joseph A;
- Chan, Jefferson;
- Kaluarachchi, Harini;
- Muchenditsi, Abigael;
- Pendyala, Venkata S;
- Jia, Shang;
- Aron, Allegra T;
- Ackerman, Cheri M;
- Wal, Mark N Vander;
- Guan, Timothy;
- Smaga, Lukas P;
- Farhi, Samouil L;
- New, Elizabeth J;
- Lutsenko, Svetlana;
- Chang, Christopher J
Published Web Location
https://doi.org/10.1038/nchembio.2098Abstract
Biochemical analysis, and imaging using a copper-sensitive fluorescent sensor, demonstrate that copper regulates cAMP-mediated lipolysis by inhibiting the activity of the cAMP-degrading phosphodiesterase PDE3B.
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