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Can increased visceral adiposity without body weight changes accelerate carotid atherosclerosis in South Korean participants with type 2 diabetes?

  • Author(s): Kim, CS
  • Kim, SK
  • Araneta, MRG
  • Lee, EJ
  • Barrett-Connor, E
  • Huh, KB
  • et al.
Abstract

© 2015. Aims: Type 2 diabetes mellitus (T2DM) and visceral obesity are associated with each other and with cardiovascular diseases. We determined whether increased visceral adiposity without weight gain was associated with sex-specific accelerated carotid atherosclerosis in South Koreans with T2DM. Methods: From 2003 to 2012, we recruited 280 participants with T2DM for the Seoul Metabolic Syndrome cohort who had body weight, visceral fat thickness (VFT), and carotid intima-media thickness (CIMT) measured at intervals of 2. years. According to VFT change, sex-specific quartiles of clinical characteristics and changes of CIMT were determined. Logistic regression models predicted the odds of the progression of CIMTs in each quartile. Results: During 2. years of observation, VFTs fell by 5.2. ±. 13.5. mm in men (P <. 0.001) and 3.4. ±. 10.5. mm in women (P <. 0.001). Progression of CIMT was only significant for women's maximal CIMT (0.031. ±. 0.145. mm, P = 0.012), while significant improvements in HbA1c were found (0.9%; P <. 0.001 in both sexes). There were no significant differences in clinical characteristics, or in progression of CIMT in men or women according to 2-year quartiles of VFT change. Conclusions: Our results do not suggest that increased visceral adiposity without body weight changes impacts the CIMT progression in South Korean men or women with T2DM.

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