Tuning Multiple Motor Travel via Single Motor Velocity.; presented at the 2012 ASCB Annual Meeting.
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Tuning Multiple Motor Travel via Single Motor Velocity.; presented at the 2012 ASCB Annual Meeting.

  • Author(s): Xu, J
  • Shu, Z
  • King, J
  • Gross, SP
  • et al.
Creative Commons Attribution 4.0 International Public License
Abstract

Microtubule-based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple-motor-based motion to various single molecule properties. Whereas both single motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single-motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between singlemotor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single-motor velocity in regulating multiple-motor transport.

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