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Physical Activity is Associated with Better Neurocognitive and Everyday Functioning Among Older Adults with HIV Disease.

  • Author(s): Fazeli, Pariya L
  • Marquine, Maria J
  • Dufour, Catherine
  • Henry, Brook L
  • Montoya, Jessica
  • Gouaux, Ben
  • Moore, Raeanne C
  • Letendre, Scott L
  • Woods, Steven Paul
  • Grant, Igor
  • Jeste, Dilip V
  • Moore, David J
  • HNRP Group
  • et al.

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We examined the association between physical activity (PA), neurocognitive impairment (NCI), and instrumental activities of daily living (IADLs) among older HIV+ persons. One hundred older HIV+ adults completed the International Physical Activity Questionnaire, a neurocognitive battery, and IADL scale. Higher levels of moderate PA were associated with lower odds of NCI (p = 0.01), even when covariates were modeled. The association between moderate PA and NCI was driven by executive function (p = 0.04). Higher levels of moderate PA were also associated with lower odds of IADL Dependence (p = 0.03), although this fell to a trend (p = 0.08) when including covariates. Follow-up analysis showed those with both NCI and IADL Dependence had lower moderate PA than those with neither (p = 0.03). While these cross-sectional findings suggest PA is associated with better neurocognitive and everyday functioning in older HIV+ adults, longitudinal studies utilizing objective PA methods are needed to evaluate directionality and mechanisms.

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