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Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
- Ji, Sun-Gou;
- Juran, Brian D;
- Mucha, Sören;
- Folseraas, Trine;
- Jostins, Luke;
- Melum, Espen;
- Kumasaka, Natsuhiko;
- Atkinson, Elizabeth J;
- Schlicht, Erik M;
- Liu, Jimmy Z;
- Shah, Tejas;
- Gutierrez-Achury, Javier;
- Boberg, Kirsten M;
- Bergquist, Annika;
- Vermeire, Severine;
- Eksteen, Bertus;
- Durie, Peter R;
- Farkkila, Martti;
- Müller, Tobias;
- Schramm, Christoph;
- Sterneck, Martina;
- Weismüller, Tobias J;
- Gotthardt, Daniel N;
- Ellinghaus, David;
- Braun, Felix;
- Teufel, Andreas;
- Laudes, Mattias;
- Lieb, Wolfgang;
- Jacobs, Gunnar;
- Beuers, Ulrich;
- Weersma, Rinse K;
- Wijmenga, Cisca;
- Marschall, Hanns-Ulrich;
- Milkiewicz, Piotr;
- Pares, Albert;
- Kontula, Kimmo;
- Chazouillères, Olivier;
- Invernizzi, Pietro;
- Goode, Elizabeth;
- Spiess, Kelly;
- Moore, Carmel;
- Sambrook, Jennifer;
- Ouwehand, Willem H;
- Roberts, David J;
- Danesh, John;
- Floreani, Annarosa;
- Gulamhusein, Aliya F;
- Eaton, John E;
- Schreiber, Stefan;
- Coltescu, Catalina;
- Bowlus, Christopher L;
- Luketic, Velimir A;
- Odin, Joseph A;
- Chopra, Kapil B;
- Kowdley, Kris V;
- Chalasani, Naga;
- Manns, Michael P;
- Srivastava, Brijesh;
- Mells, George;
- Sandford, Richard N;
- Alexander, Graeme;
- Gaffney, Daniel J;
- Chapman, Roger W;
- Hirschfield, Gideon M;
- de Andrade, Mariza;
- Rushbrook, Simon M;
- Franke, Andre;
- Karlsen, Tom H;
- Lazaridis, Konstantinos N;
- Anderson, Carl A
Published Web Location
https://doi.org/10.1038/ng.3745Abstract
Konstantinos Lazaridis, Carl Anderson and colleagues report results of a genome-wide association study of primary sclerosing cholangitis (PSC). They identify four new susceptibility loci for PSC and quantify the correlation of common genetic variation shared between PSC and inflammatory bowel diseases.
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