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Open Access Publications from the University of California

Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.

  • Author(s): Saravanan, Shanmugam
  • Gomathi, Selvamurthi
  • Kausalya, Bagavathi
  • Boobalan, Jayaseelan
  • Murugavel, Kailapuri G
  • Balakrishnan, Pachamuthu
  • Mothi, Sarvode N
  • Solomon, Sunil S
  • Kumarasamy, Nagalingeswaran
  • Selvamuthu, Poongulali
  • Solomon, Suniti
  • Smith, Davey M
  • et al.

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In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

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