UC Santa Cruz

The work by Mizukami et al., published in this issue, describes precise genomic breakpoints on 18 lung adenocarcinoma samples with oncogenic RET rearrangements, which occur in ~2% of lung adenocarcinomas. Sequence analysis indicates that breakpoints occur at non-specific sites, using variable mechanisms for DNA repair. This study provides important information for the development of molecular tests for this genomic rearrangement.