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Breaking Down RET Breakpoints in Lung Adenocarcinoma
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https://doi.org/10.1097/jto.0000000000000168Abstract
The work by Mizukami et al., published in this issue, describes precise genomic breakpoints on 18 lung adenocarcinoma samples with oncogenic RET rearrangements, which occur in ~2% of lung adenocarcinomas. Sequence analysis indicates that breakpoints occur at non-specific sites, using variable mechanisms for DNA repair. This study provides important information for the development of molecular tests for this genomic rearrangement.
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