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Broad-spectrum allosteric inhibition of herpesvirus proteases
Published Web Location
http://europepmc.org/articles/PMC4108181?pdf=renderNo data is associated with this publication.
Abstract
Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposis sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two an
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