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Broad-spectrum allosteric inhibition of herpesvirus proteases

  • Author(s): Craik, Charles
  • Renslo, Adam
  • Gable, JE
  • Lee, GM
  • Jaishankar, P
  • Hearn, BR
  • Waddling, CA
  • Renslo, AR
  • Craik, CS
  • et al.

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Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposis sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two an

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