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Structural basis for alternating access of a eukaryotic calcium/proton exchanger

et al.

Published Web Location

https://doi.org/10.1038/nature12233
Abstract

The X-ray crystal structure of a member of the Ca2+/H+ (CAX) antiporter family from Saccharomyces cerevisiae in a cytosol-facing, substrate-bound conformation is solved; using the structure, a mechanism by which members of the Ca2+:cation (CaCA) superfamily facilitate Ca2+ transport across cellular membranes is proposed.

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