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Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination
- Jacob, Christopher G;
- Thuy-Nhien, Nguyen;
- Mayxay, Mayfong;
- Maude, Richard J;
- Quang, Huynh Hong;
- Hongvanthong, Bouasy;
- Vanisaveth, Viengxay;
- Ngo Duc, Thang;
- Rekol, Huy;
- van der Pluijm, Rob;
- von Seidlein, Lorenz;
- Fairhurst, Rick;
- Nosten, François;
- Hossain, Md Amir;
- Park, Naomi;
- Goodwin, Scott;
- Ringwald, Pascal;
- Chindavongsa, Keobouphaphone;
- Newton, Paul;
- Ashley, Elizabeth;
- Phalivong, Sonexay;
- Maude, Rapeephan;
- Leang, Rithea;
- Huch, Cheah;
- Dong, Le Thanh;
- Nguyen, Kim-Tuyen;
- Nhat, Tran Minh;
- Hien, Tran Tinh;
- Nguyen, Hoa;
- Zdrojewski, Nicole;
- Canavati, Sara;
- Sayeed, Abdullah Abu;
- Uddin, Didar;
- Buckee, Caroline;
- Fanello, Caterina I;
- Onyamboko, Marie;
- Peto, Thomas;
- Tripura, Rupam;
- Amaratunga, Chanaki;
- Myint Thu, Aung;
- Delmas, Gilles;
- Landier, Jordi;
- Parker, Daniel M;
- Chau, Nguyen Hoang;
- Lek, Dysoley;
- Suon, Seila;
- Callery, James;
- Jittamala, Podjanee;
- Hanboonkunupakarn, Borimas;
- Pukrittayakamee, Sasithon;
- Phyo, Aung Pyae;
- Smithuis, Frank;
- Lin, Khin;
- Thant, Myo;
- Hlaing, Tin Maung;
- Satpathi, Parthasarathi;
- Satpathi, Sanghamitra;
- Behera, Prativa K;
- Tripura, Amar;
- Baidya, Subrata;
- Valecha, Neena;
- Anvikar, Anupkumar R;
- Ul Islam, Akhter;
- Faiz, Abul;
- Kunasol, Chanon;
- Drury, Eleanor;
- Kekre, Mihir;
- Ali, Mozam;
- Love, Katie;
- Rajatileka, Shavanthi;
- Jeffreys, Anna E;
- Rowlands, Kate;
- Hubbart, Christina S;
- Dhorda, Mehul;
- Vongpromek, Ranitha;
- Kotanan, Namfon;
- Wongnak, Phrutsamon;
- Almagro Garcia, Jacob;
- Pearson, Richard D;
- Ariani, Cristina V;
- Chookajorn, Thanat;
- Malangone, Cinzia;
- Nguyen, T;
- Stalker, Jim;
- Jeffery, Ben;
- Keatley, Jonathan;
- Johnson, Kimberly J;
- Muddyman, Dawn;
- Chan, Xin Hui S;
- Sillitoe, John;
- Amato, Roberto;
- Simpson, Victoria;
- Gonçalves, Sonia;
- Rockett, Kirk;
- Day, Nicholas P;
- Dondorp, Arjen M;
- Kwiatkowski, Dominic P;
- Miotto, Olivo
- et al.
Published Web Location
https://elifesciences.org/articles/62997No data is associated with this publication.
Abstract
Background
National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.Methods
Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs.Results
GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs.Conclusions
GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.Funding
The GenRe-Mekong project is funded by the Bill and Melinda Gates Foundation (OPP11188166, OPP1204268). Genotyping and sequencing were funded by the Wellcome Trust (098051, 206194, 203141, 090770, 204911, 106698/B/14/Z) and Medical Research Council (G0600718). A proportion of samples were collected with the support of the UK Department for International Development (201900, M006212), and Intramural Research Program of the National Institute of Allergy and Infectious Diseases.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.