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Open Access Publications from the University of California

Zebrafish for modeling skin disorders

  • Author(s): Cline, Abigail
  • Feldman, Steven R
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

The experimental advantages of zebrafish make this model system highly amenable to the field of dermatology. Zebrafish skin development is similar to humans and its genome is ~70% orthologous to the human genome. Its external developmental process allows for genetic manipulation and analysis of embryogenesis within a short time frame with all important internal organs and skin compartments formed within 6 days. Zebrafish models of cutaneous human diseases offer insight into pathogenesis and a unique platform for testing of potential therapies. This review details the specific advantages of zebrafish and highlights its use in dermatological research.

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