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NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
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https://doi.org/10.1038/nsmb.2990Abstract
MLL1 regulates circadian promoters by depositing H3K4 trimethyl marks, whose levels are also modulated by the NAD+-dependent deacetylase SIRT1. SIRT1 is now shown to promote circadian deacetylation of MLL1, thus affecting MLL1's methyltransferase activity.
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