Skip to main content
eScholarship
Open Access Publications from the University of California

Genome-wide association study identifies eight loci associated with blood pressure.

  • Author(s): Newton-Cheh, Christopher
  • Johnson, Toby
  • Gateva, Vesela
  • Tobin, Martin D
  • Bochud, Murielle
  • Coin, Lachlan
  • Najjar, Samer S
  • Zhao, Jing Hua
  • Heath, Simon C
  • Eyheramendy, Susana
  • Papadakis, Konstantinos
  • Voight, Benjamin F
  • Scott, Laura J
  • Zhang, Feng
  • Farrall, Martin
  • Tanaka, Toshiko
  • Wallace, Chris
  • Chambers, John C
  • Khaw, Kay-Tee
  • Nilsson, Peter
  • van der Harst, Pim
  • Polidoro, Silvia
  • Grobbee, Diederick E
  • Onland-Moret, N Charlotte
  • Bots, Michiel L
  • Wain, Louise V
  • Elliott, Katherine S
  • Teumer, Alexander
  • Luan, Jian'an
  • Lucas, Gavin
  • Kuusisto, Johanna
  • Burton, Paul R
  • Hadley, David
  • McArdle, Wendy L
  • Wellcome Trust Case Control Consortium
  • Brown, Morris
  • Dominiczak, Anna
  • Newhouse, Stephen J
  • Samani, Nilesh J
  • Webster, John
  • Zeggini, Eleftheria
  • Beckmann, Jacques S
  • Bergmann, Sven
  • Lim, Noha
  • Song, Kijoung
  • Vollenweider, Peter
  • Waeber, Gerard
  • Waterworth, Dawn M
  • Yuan, Xin
  • Groop, Leif
  • Orho-Melander, Marju
  • Allione, Alessandra
  • Di Gregorio, Alessandra
  • Guarrera, Simonetta
  • Panico, Salvatore
  • Ricceri, Fulvio
  • Romanazzi, Valeria
  • Sacerdote, Carlotta
  • Vineis, Paolo
  • Barroso, Inês
  • Sandhu, Manjinder S
  • Luben, Robert N
  • Crawford, Gabriel J
  • Jousilahti, Pekka
  • Perola, Markus
  • Boehnke, Michael
  • Bonnycastle, Lori L
  • Collins, Francis S
  • Jackson, Anne U
  • Mohlke, Karen L
  • Stringham, Heather M
  • Valle, Timo T
  • Willer, Cristen J
  • Bergman, Richard N
  • Morken, Mario A
  • Döring, Angela
  • Gieger, Christian
  • Illig, Thomas
  • Meitinger, Thomas
  • Org, Elin
  • Pfeufer, Arne
  • Wichmann, H Erich
  • Kathiresan, Sekar
  • Marrugat, Jaume
  • O'Donnell, Christopher J
  • Schwartz, Stephen M
  • Siscovick, David S
  • Subirana, Isaac
  • Freimer, Nelson B
  • Hartikainen, Anna-Liisa
  • McCarthy, Mark I
  • O'Reilly, Paul F
  • Peltonen, Leena
  • Pouta, Anneli
  • de Jong, Paul E
  • Snieder, Harold
  • van Gilst, Wiek H
  • Clarke, Robert
  • Goel, Anuj
  • Hamsten, Anders
  • Peden, John F
  • Seedorf, Udo
  • Syvänen, Ann-Christine
  • Tognoni, Giovanni
  • Lakatta, Edward G
  • Sanna, Serena
  • Scheet, Paul
  • Schlessinger, David
  • Scuteri, Angelo
  • Dörr, Marcus
  • Ernst, Florian
  • Felix, Stephan B
  • Homuth, Georg
  • Lorbeer, Roberto
  • Reffelmann, Thorsten
  • Rettig, Rainer
  • Völker, Uwe
  • Galan, Pilar
  • Gut, Ivo G
  • Hercberg, Serge
  • Lathrop, G Mark
  • Zelenika, Diana
  • Deloukas, Panos
  • Soranzo, Nicole
  • Williams, Frances M
  • Zhai, Guangju
  • Salomaa, Veikko
  • Laakso, Markku
  • Elosua, Roberto
  • Forouhi, Nita G
  • Völzke, Henry
  • Uiterwaal, Cuno S
  • van der Schouw, Yvonne T
  • Numans, Mattijs E
  • Matullo, Giuseppe
  • Navis, Gerjan
  • Berglund, Göran
  • Bingham, Sheila A
  • Kooner, Jaspal S
  • Connell, John M
  • Bandinelli, Stefania
  • Ferrucci, Luigi
  • Watkins, Hugh
  • Spector, Tim D
  • Tuomilehto, Jaakko
  • Altshuler, David
  • Strachan, David P
  • Laan, Maris
  • Meneton, Pierre
  • Wareham, Nicholas J
  • Uda, Manuela
  • Jarvelin, Marjo-Riitta
  • Mooser, Vincent
  • Melander, Olle
  • Loos, Ruth JF
  • Elliott, Paul
  • Abecasis, Gonçalo R
  • Caulfield, Mark
  • Munroe, Patricia B
  • et al.

Published Web Location

https://doi.org/10.1038/ng.361
Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View