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Genomic insights into TASK-1 reveal functional roles in sleep apnea
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https://doi.org/10.1038/s41588-022-01195-9Abstract
KCNK3 mutations identified in sleep apnea probands affect TASK-1 X-gate function. These changes lead to an increase in potassium current and open probability, as well as impaired sensitivity to G-protein-coupled receptor inhibitors.
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