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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
- Pugh, Trevor J;
- Weeraratne, Shyamal Dilhan;
- Archer, Tenley C;
- Pomeranz Krummel, Daniel A;
- Auclair, Daniel;
- Bochicchio, James;
- Carneiro, Mauricio O;
- Carter, Scott L;
- Cibulskis, Kristian;
- Erlich, Rachel L;
- Greulich, Heidi;
- Lawrence, Michael S;
- Lennon, Niall J;
- McKenna, Aaron;
- Meldrim, James;
- Ramos, Alex H;
- Ross, Michael G;
- Russ, Carsten;
- Shefler, Erica;
- Sivachenko, Andrey;
- Sogoloff, Brian;
- Stojanov, Petar;
- Tamayo, Pablo;
- Mesirov, Jill P;
- Amani, Vladimir;
- Teider, Natalia;
- Sengupta, Soma;
- Francois, Jessica Pierre;
- Northcott, Paul A;
- Taylor, Michael D;
- Yu, Furong;
- Crabtree, Gerald R;
- Kautzman, Amanda G;
- Gabriel, Stacey B;
- Getz, Gad;
- Jäger, Natalie;
- Jones, David TW;
- Lichter, Peter;
- Pfister, Stefan M;
- Roberts, Thomas M;
- Meyerson, Matthew;
- Pomeroy, Scott L;
- Cho, Yoon-Jae
Published Web Location
https://doi.org/10.1038/nature11329Abstract
Medulloblastoma is the most common brain tumour in children; using exome sequencing of tumour samples the authors show that these cancers have low mutation rates and identify 12 significantly mutated genes, among them the gene encoding RNA helicase DDX3X.
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