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Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

  • Author(s): Rosenthal, Philip
  • Greenhouse, Bryan
  • Gong, L
  • Parikh, S
  • Rosenthal, PJ
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3847285?pdf=render
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Abstract

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemica

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