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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
- Shojaee, Seyedmehdi;
- Chan, Lai N;
- Buchner, Maike;
- Cazzaniga, Valeria;
- Cosgun, Kadriye Nehir;
- Geng, Huimin;
- Qiu, Yi Hua;
- von Minden, Marcus Dühren;
- Ernst, Thomas;
- Hochhaus, Andreas;
- Cazzaniga, Giovanni;
- Melnick, Ari;
- Kornblau, Steven M;
- Graeber, Thomas G;
- Wu, Hong;
- Jumaa, Hassan;
- Müschen, Markus
Published Web Location
https://doi.org/10.1038/nm.4062Abstract
As opposed to its tumor suppressor role in other cancers, PTEN inhibition in pre-B ALL is therapeutically effective and triggers cell death.
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