Skip to main content
Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise.
- Author(s): Hong, Cheng William;
- Hamilton, Gavin;
- Hooker, Catherine;
- Park, Charlie C;
- Tran, Calvin Andrew;
- Henderson, Walter C;
- Hooker, Jonathan C;
- Fazeli Dehkordy, Soudabeh;
- Schwimmer, Jeffrey B;
- Reeder, Scott B;
- Sirlin, Claude B
- et al.
Published Web Locationhttps://link.springer.com/article/10.1007%2Fs00261-019-02079-z
No data is associated with this publication.
PurposeThis study compares splenic proton density fat fraction (PDFF) measured using confounder-corrected chemical shift-encoded (CSE)-MRI to magnetic resonance spectroscopy (MRS) in human patients at 3T.
MethodsThis was a prospectively designed ancillary study to various previously described single-center studies performed in adults and children with known or suspected nonalcoholic fatty liver disease. Patients underwent magnitude-based MRI (MRI-M), complex-based MRI (MRI-C), high signal-to-noise variants (Hi-SNR MRI-M and Hi-SNR MRI-C), and MRS at 3T for spleen PDFF estimation. PDFF from CSE-MRI methods were compared to MRS-PDFF using Wilcoxon signed-rank tests. Demographics were summarized descriptively. Spearman's rank correlations were computed pairwise between CSE-MRI methods. Individual patient measurements were plotted for qualitative assessment. A significance level of 0.05 was used.
ResultsForty-seven patients (20 female, 27 male) including 12 adults (median 55 years old) and 35 children (median 12 years old). Median PDFF estimated by MRS, MRI-M, Hi-SNR MRI-M, MRI-C, and Hi-SNR MRI-C was 1.0, 2.3, 1.9, 2.2, and 2.0%. The four CSE-MRI methods estimated statistically significant higher spleen PDFF values compared to MRS (p < 0.0001 for all). Pairwise associations in spleen PDFF values measured by different CSE-MRI methods were weak, with the highest Spearman's rank correlations being 0.295 between MRI-M and Hi-SNR MRI-M; none were significant after correction for multiple comparisons. No qualitative relationship was observed between PDFF measurements among the various methods.
ConclusionOverestimation of PDFF by CSE-MRI compared to MRS and poor agreement between related CSE-MRI methods suggest that non-zero PDFF values in human spleen are artifactual.
Item not freely available? Link broken?Report a problem accessing this item