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Open Access Publications from the University of California

Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells.

  • Author(s): Meinert, Christian
  • Kohse, Franziska
  • Böhme, Ilka
  • Gembardt, Florian
  • Tetzner, Anja
  • Wieland, Thomas
  • Greenberg, Barry
  • Walther, Thomas
  • et al.

In 2016, Meinert et al. (doi: 10.1016/j.jprot.2015.09.020) published the first 25 proteins in a protein array regulated in Human Umbilical Vein Endothelial Cells (HUVEC) by the heptapeptide angiotensin (Ang)-(1-7) and the first 10 intracellular signaling cascades at different time points. This supporting data article shows further proteins and pathways stimulated by Ang-(1-7) in human endothelial cells at time points of 1 h, 3 h, 6 h, and 9 h. HUVECs were stimulated with Ang-(1-7), and regulated proteins were identified via antibody microarray. Bioinformatics software IPA was used for association of regulated proteins to metabolic pathways.

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