Shifting the Evolving CAR T Cell Platform into Higher Gear.
- Author(s): Holohan, Daniel R;
- Lee, James C;
- Bluestone, Jeffrey A
- et al.
Published Web Locationhttps://doi.org/10.1016/j.ccell.2015.09.014
In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion. The results have important implications for the development of effective CAR T cell therapies in cancer patients.