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Shifting the Evolving CAR T Cell Platform into Higher Gear.

  • Author(s): Holohan, Daniel R
  • Lee, James C
  • Bluestone, Jeffrey A
  • et al.
Abstract

In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion. The results have important implications for the development of effective CAR T cell therapies in cancer patients.

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