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Open Access Publications from the University of California

Shifting the Evolving CAR T Cell Platform into Higher Gear

  • Author(s): Holohan, DR
  • Lee, JC
  • Bluestone, JA
  • et al.

© 2015 Elsevier Inc. In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion. The results have important implications for the development of effective CAR T cell therapies in cancer patients.

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