Shifting the Evolving CAR T Cell Platform into Higher Gear
- Author(s): Holohan, DR
- Lee, JC
- Bluestone, JA
- et al.
Published Web Locationhttps://doi.org/10.1016/j.ccell.2015.09.014
© 2015 Elsevier Inc. In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion. The results have important implications for the development of effective CAR T cell therapies in cancer patients.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.